Bloating. Shifting pain. Urgency. Symptoms that come and go without explanation, and an IBS diagnosis that never quite felt right.
For millions of people in the UK, the real answer takes years longer than it should.
Gut Autoimmunity tests five markers from a single blood draw, covering the autoimmune conditions most likely to be missed or misread.
What we measure and why it matters
- Deamidated gliadin peptide and transglutaminase IgA: whether your immune system may be reacting to gluten. Together they form one of the most accurate combinations available for flagging a possible immune response, whether that points toward coeliac disease or non-coeliac gluten sensitivity.
- pANCA and ASCA: antibodies that can suggest inflammation in the gut wall, helping build a picture of whether Crohn's disease or ulcerative colitis may be a factor in a way no single marker can on its own.
- Total immunoglobulins: your overall antibody levels. An IgA deficiency can affect how reliable your other results are and is worth knowing about before drawing any conclusions.
One thing to know before you test
You need to have been eating gluten regularly for at least 6 weeks before your sample is taken. If you've been avoiding gluten, your results may not reflect your true immune response.
Who this is for
If you need clearer answers for ongoing gut symptoms, or your mOI Immune Core results have flagged something worth following up, this is where the picture starts to get clearer.
Sample type: Venous blood (at-home phlebotomy or a location convenient to you)
What's tested: Deamidated gliadin peptide (DGP), transglutaminase IgA, perinuclear ANCA (pANCA), Saccharomyces Cerevisiae Antibodies (ASCA), total immunoglobulins (IgG, IgM, IgA)
Phlebotomy billed separately: A £99 service fee will be added as a separate line item at checkout. This isn’t included in the cost of your test.
Results in: We aim to get your results to you within 10 working days of your sample reaching the lab. Occasionally it takes a little longer for reasons outside our control. Turnaround times are estimates, not guarantees, and are subject to our Terms and Conditions of Sale.
Your test, in detail
Bloating. Pain that moves around. Urgency. Symptoms that come and go without explanation, and a diagnosis of IBS that never quite felt right. For millions of people in the UK, the real answer takes years longer than it should.
Gut Autoimmunity tests five markers from a single blood draw, covering the autoimmune conditions most likely to be missed or misread.
Two markers look at whether your immune system may be reacting to gluten. Deamidated gliadin peptide and transglutaminase IgA together form one of the most sensitive and specific combinations available for flagging a possible immune response to gluten, whether that points toward coeliac disease or non-coeliac gluten sensitivity.
A further two, pANCA and ASCA (antibodies that can indicate inflammation in the gut wall), can help build a picture of whether Crohn's disease or ulcerative colitis may be a factor, in a way that no single marker can do alone.
The fifth, total immunoglobulins (the full range of antibodies your immune system produces), checks your overall antibody levels, because an IgA deficiency (a common immune condition where one key antibody type is low or absent) can affect the reliability of your other results and is worth knowing about before drawing any conclusions.
Total immunoglobulins (IgG, IgM, IgA) are the three main classes of antibody your immune system produces. Each plays a different role:
- IgG: the most abundant antibody in your blood, and the main one that provides long-term protection after infection or vaccination. Chronically elevated or depleted levels can both be meaningful.
- IgM: the first antibody your immune system produces when it encounters something new. Elevated levels can signal an active or recent immune response.
- IgA: the antibody that lines your gut, airways, and mucous membranes. Low levels are common in people with coeliac disease and can affect how other gut autoantibody tests are interpreted.
One important thing to consider when purchasing and before your sample is taken: you need to have been eating gluten regularly for at least 6 weeks for your coeliac results to be accurate. If you've been avoiding gluten, your results may not reflect your true immune response.
If you need clear answers for your gut symptoms, or your mOI Immune Core results have flagged something worth following up, this is where the picture starts to get clearer.
Once your kit arrives, you'll book a visit with a trained phlebotomist at your home or a location convenient to you. Appointments are available between 8am and 2pm, Monday to Wednesday. Your sample is collected using professional methods, centrifuged on-site to preserve quality, and prepared for secure delivery to the lab. Everything is handled for you from start to finish.
Deamidated Gliadin Peptide (DGP) When your immune system reacts to gluten, it produces antibodies against gliadin, the protein component of gluten. DGP measures those antibodies. It is one of the earliest and most sensitive markers for coeliac disease, and particularly useful for picking up cases that other markers may miss, including in people with an IgA deficiency that would make other coeliac markers unreliable. For results to be accurate, you need to have been eating gluten regularly for at least 6 weeks before testing.
Transglutaminase IgA (tTG IgA) In coeliac disease, the immune system can mistakenly target an enzyme called tissue transglutaminase in the gut lining. The IgA antibody produced in response is the most specific marker for coeliac disease available from a blood test. Elevated levels suggest an immune response may be affecting the gut lining, and give your clinical team something concrete to work with. As with DGP, results are only reliable if you have been eating gluten regularly for at least 6 weeks before testing. A gluten-free diet before testing can produce a false negative.
Perinuclear ANCA (pANCA) pANCA is an autoantibody found in a significant proportion of people with ulcerative colitis. Its presence doesn't confirm a diagnosis, and its absence doesn't rule one out. Combined with ASCA, it helps build a clearer picture of whether IBD may be present, and which type is more likely.
Saccharomyces Cerevisiae Antibodies (ASCA) ASCA is an autoantibody more commonly associated with Crohn's disease. Like pANCA, it doesn't work in isolation, and a negative result doesn't exclude the condition. Together, the 2 markers have a stronger ability to help differentiate between Crohn's and ulcerative colitis than either does alone. If symptoms persist despite negative results, further investigation with your clinical team remains important.
Total Immunoglobulins (IgG, IgM, IgA) Immunoglobulins are your body's antibodies. Measuring all three classes gives a picture of your overall antibody levels and helps ensure your other results are read in the right context. IgA matters most here: selective IgA deficiency affects around 1 in 500 people and can cause coeliac markers to appear normal even when coeliac disease is present. Where IgA is low, deamidated gliadin peptide provides a more reliable alternative. Checking total immunoglobulins means nothing gets misread for the wrong reason.
- Drink at least 500ml of water in the 2 hours beforehand. Good hydration makes the draw easier and improves sample quality.
- Fast for at least 8 hours before your appointment. Overnight fasting works well. Some markers, particularly lipids and glucose, are significantly more accurate when measured in a fasted state.
- Continue taking any prescribed medication as normal unless your clinician has advised otherwise. If you take blood thinners or have a bleeding or clotting condition, please let your phlebotomist know before the draw.
- Your phlebotomist will apply a cotton pad to the puncture site. Keeping your arm straight for a few minutes helps.
- A plaster may be applied to cover the area. If you have a plaster allergy, let your phlebotomist know beforehand.
- Try to keep the dressing on for at least an hour to reduce the chance of bruising and keep the area clean.
- If you've felt faint after a blood draw before, mention it to your phlebotomist so they can keep an eye on you.
- Some light bruising is normal and should fade within a few days.
- If you feel unwell after your test, contact your GP or local NHS service for advice.
- For more on what to expect, you can visit the NHS website: https://www.nhs.uk/tests-and-treatments/blood-tests/.
This panel measures five autoantibody markers associated with coeliac disease, gluten sensitivity, IBD, and IgA deficiency. Autoantibody levels can vary depending on a range of factors, including diet, medication, and the stage of a condition. A normal result doesn't rule out a condition, and an elevated result doesn't confirm one. For the coeliac markers to be accurate, you'll need to have been eating gluten regularly for at least 6 weeks before your test.
This test doesn't provide a diagnosis. Your results are intended to support your understanding of your own biology and may help inform conversations with your clinical team. They shouldn't be used as the sole basis for any medical decision.
mOI is a registered as a Class I Software as a Medical Device. This test isn't a substitute for clinical assessment or advice from a qualified healthcare professional.
A structured path to Immune Intelligence
Choose your test
Select the test that’s right for you
Start with what you want to explore or understand
Receive your kit
Your test kit is delivered to your door
Everything you need, ready for your sample
Provide your sample
Follow the instructions in your kit or book an at home visit for blood collection.
Simple, guided steps depending on your test
Send your sample to the lab
Your sample is securely prepared and
sent for analysis
Handled with care to maintain quality
View your results and insights
See your results in the app, connected to your health over time
Helping you make sense of what’s changing
Choose your test
Select the test that’s right for you
Start with what you want to explore or understand
Receive your kit
Your test kit is delivered to your door
Everything you need, ready for your sample
Provide your sample
Follow the instructions in your kit or book an at home visit for blood collection.
Simple, guided steps depending on your test
Send your sample to the lab
Your sample is securely prepared and
sent for analysis
Handled with care to maintain quality
View your results and insights
See your results in the app, connected to your health over time
Helping you make sense of what’s changing
Frequently asked questions
mOI Gut Autoimmunity gives you a five-marker picture of your gut's immune activity. Deamidated gliadin peptide and transglutaminase IgA tell you whether your immune system may be reacting to gluten, whether that points toward coeliac disease or non-coeliac gluten sensitivity, or attacking the gut lining directly. pANCA and ASCA help indicate whether IBD may be present and, if so, whether it points more toward Crohn's or ulcerative colitis. Total immunoglobulins check your overall antibody levels, because a deficiency in IgA can affect the accuracy of your coeliac results and needs to be accounted for. Together, they give you a clearer picture of what may be driving your gut symptoms than symptoms alone can provide.
Gut Autoimmunity is for anyone who has been living with persistent gut symptoms and wants to understand whether their immune system may be involved. It's particularly relevant if you've been told you might have IBS but aren't convinced, if you're experiencing symptoms that could point toward coeliac disease, gluten sensitivity, or IBD, or if you have a personal or family history of any of these conditions. One important thing to consider when purchasing and before your sample is taken: you need to have been eating gluten regularly for at least 6 weeks for your coeliac results to be accurate. If you've been avoiding gluten, your results may not reflect your true immune response. If you're unsure whether this test is right for you, speak to your GP or clinical team before purchasing.
We aim to get your results to you as quickly as possible once your sample reaches the lab, though turnaround times vary by test and occasionally take a little longer for reasons outside our control. Turnaround times are estimates, not guarantees, and are subject to our Terms and Conditions of Sale. Most results appear directly in the mOI app, linked to your health record. They sit alongside your tracking data and insights rather than arriving as a standalone report. For some tests, including certain gut health results, you may receive a PDF report instead of in-app results. Where this applies, it will be made clear at the time. If your membership has lapsed or been cancelled when results become available, we'll deliver them to the email address held in your account instead.
Your results are designed to support your understanding of your gut health, not to replace clinical advice. These markers are most useful when read alongside your broader health data, including your Immune Core results and, where available, your genomic data. If anything in your results concerns you, or if you'd like to discuss what they mean in the context of your wider health, share them with your GP or clinical team.
Yes. Testing is only available with a paid mOI membership, and tests are priced separately. Membership gives you access to the full platform, including your results, longitudinal tracking, and the insights that connect your data over time. If you're not a member yet, you can create an account to get started.